منابع مشابه
Heterogeneity of estrogen binding sites in the cytosol of the rat uterus.
Saturation analysis over a wide range of [3H]estradiol concentrations (0.05 to 80 IBM) yields data indicative of two distinct types of binding sites in cytosol prepared from uteri of mature or immature rats. Type I sites have a dissociation constant (&) of 0.8 nM and constitute approximately 1.0 pmol of the sites present in an immature rat uterus (wet weight, 35 mg; DNA, 300 pg). The affinity o...
متن کاملEstrogen receptors in the rat uterus. Studies on the interaction of cytosol and nuclear binding sites.
Studies on the interrelationship of binding sites for estrogens found in cytosol and nuclear fractions of the rat uterus show that 17/3-estradiol is f&t associated with a protein (9 S) present in the cytosol. The estrogen subsequently moves into the nucleus where it is bound to a protein (5 S) which can be extracted from the chromatin. Simultaneously with the movement of the estrogen into the n...
متن کامل[Effect of estrogen on glycogen synthesis in the rat uterus].
It is well known that an increase in glycogen content is one of the metabolic changes which estrogen induces in rat uterus, the target organ of the hormone . Although glycogen in the uterus has been considered to be an energy and nutritional source for the implan tation and growth of fertilized ovum, the mechanism of glycogen synthesis in the uterus and the biological significance of the elevat...
متن کامل[Estrogen receptors of the rat uterus during pregnancy and lactation].
Uterine estrogen receptors (ER) of the rat during pregnancy and postpartal lactation were assayed. Both the cytoplasmic and nuclear ER were determined by the controlled pore glass (CPG) method as previously described in detail. The cytoplasmic ER level slightly decreased as pregnancy advanced and then increased remarkably during postpartal lactation, with a tendency to decrease at 5 weeks of la...
متن کاملArsenic abrogates the estrogen-signaling pathway in the rat uterus
BACKGROUND Arsenic, a major pollutant of water as well as soil, is a known endocrine disruptor, and shows adverse effects on the female reproductive physiology. However, the exact molecular events leading to reproductive dysfunctions as a result of arsenic exposure are yet to be ascertained. This report evaluates the effect and mode of action of chronic oral arsenic exposure on the uterine phys...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1971
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62321-x